Resealed erythrocytes serve as an ideal carrier for antineoplastic agents, antimicrobial drug and vitamins and steroids. Introduction basic concept of rbc drug carrying potential of rbc advantages and limitations source and isolation of rbc. Red blood cells powerpoint template, backgrounds 02953. As a member, youll also get unlimited access to over 79,000 lessons in math, english, science, history, and more. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in. No difference was observed in the shape, size and drug content of loaded and lyophilized erythrocytes when compared with freshly loaded erythrocytes. Erythrocytes em an image from a scanning electron microscope shows the biconcave shape of erythrocytes. Erythrocytes definition of erythrocytes by medical. Biconcave shape of human redbloodcell ghosts relies on density. For loading, the rbcs membrane was opened by swelling under hypoosmotic conditions and subsequently resealed. Find erythrocytes stock images in hd and millions of other royaltyfree stock photos, illustrations and vectors in the shutterstock collection. Erythrocytes, the most abundant cells in the human body, have potential carrier capabilities for the delivery of drugs.
If you continue browsing the site, you agree to the use of cookies on this website. After every pass, aliquote of the suspension is withdrawn and centrifuged at 300 g. Contents of the powerpoint on resealed erythrocytes include. This biology lab free powerpoint theme is royalty free and could be used as themses and backgrounds for biology lab, technology, development, medicine, precision, equipment, modern, microbiology, genetics and such topics. Such cells could be used as circulating carriers to disseminate a drug within a prolonged period of time in circulation or in targetspecific organs, including the liver, spleen, and lymph nodes. Various advantages of resealed erythrocytes they are the natural product of the body, which are biodegradable in nature. Erythrocytes are biocompatible, biodegradable, possess long circulation half lives and can be loaded with a variety of biologica. Explains about low white blood cell count, high red blood cells, red blood cell production, etc. International journal of chemistry and pharmaceutical sciences. At the end of their lifecycle, they are destroyed by macrophages, and their components are recycled. Ppt red blood cells powerpoint presentation free to. The shape of the human red blood cell is known to be a biconcave disk. In humans the normal mature erythrocyte is a biconcave disk without a nucleus, about 7.
After 120 days, erythrocytes tend to lose their shape and. A free powerpoint ppt presentation displayed as a flash slide show on id. International journal of chemistry and pharmaceutical sciences 169 and serves only to carry haemoglobin. Contain the pigment haemoglobin which is essential for the uptake of oxygen in the lungs and its transport to the tissues. This shape allows red blood cells to bend and deform so that they can traverse tiny capillaries. Magnetiteloaded carrier erythrocytes as contrast agents for.
This video describes the function and structure of erythrocytes in the blood. Bone marrow red yellow bone fat reticulin haematopoiesis red, white, platelets lymphoid red cells men women hemoglobin gl 140180 120160 hematocrit % 4052. Hematology powerpoint template powerpoint template free. Isolation of erythrocytes is easy and larger amount of drug can be encapsulated in a small volume of cells. The use of erythrocytes as a controlled release of drug is predominantly devoted to small molecules that are minimally retained within erythrocytes and progressively leak from the cell into the plasmatic compartment. They protect the premature degradation, inactivation and excretion of proteins and enzymes they can target the drugs within reticuloendothelial system they facilitate incorporation of proteins and nucleic acids in eukaryotic cells by cell infusion with rbc. Study of erythrocytes as a novel drug carrier for the delivery of. Various bioactive agents encapsulated in erythrocytes are developed for the slow and sustained release in circulation to allow effective treatment of parasitic diseases. Erythrocytes also may be coated with a variety of receptors by nontransgenic methods, making this a very flexible model for the treatment of infectious diseases in humans.
Download here free healthcaremagic app to ask a doctor. Vinay kumar slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Free download the red blood cell powerpoint presentation slides. Resealed erythrocytes a specified tool in novel drug delivery system vaishali goel, charanjeet kaur, rainu devi, aman kumar, ujjwal nautiyal himachal institute of pharmacy, paonta sahib, distt. Plus, get practice tests, quizzes, and personalized coaching to help you succeed. The margins of the slides were cleaned with the alcoholic swab. Heres a list of similar words from our thesaurus that you can use instead. Erythrocyte meaning in the cambridge english dictionary. Transgenic expression of viral receptor on erythrocytes attenuates coxsackievirus b infection. The components of the degraded erythrocytes hemoglobin are further processed as follows. Resealed erythrocytes are prepared by isolating erythrocytes from the plasma of the blood sample of an organism of interest, breakdown of cells using different methods and then entrapping the drug which is to be administered into the body into the erythrocytes by various techniques such as. The use of cells as drug delivery system requires that the drug which are normally unable to permeate the membrane, should be made to traverse the membrane without causing any irreversible changes in membrane structure and. Erythrocyte casts definition of erythrocyte casts by. Resealed erythrocytes a specified tool in novel drug delivery.
Erythrocytes, also known as red blood cells, and have been extensively studied for their potential carrier capabilities for the delivery of drugs. In fact, erythrocytes are estimated to make up about 25. Characterization of human erythrocytes as potential carrier. First of all, we would like to welcome all of you to this new website. Applications of resealed erythrocytes erythrocytes as carrier for enzymes erythrocytes as carrier for drugs erythrocytes for drug targeting drug targeting to reticuloendothelial system drug targeting to liver treatment of liver tumors treatment of parasitic diseases removal of res iron overload removal of toxic agents 21. Oct 02, 20 applications of resealed erythrocytes erythrocytes as carrier for enzymes erythrocytes as carrier for drugs erythrocytes for drug targeting drug targeting to reticuloendothelial system drug targeting to liver treatment of liver tumors treatment of parasitic diseases removal of res iron overload removal of toxic agents 21. It contains information about erythrocytes red blood cells in general, their rheological behavior and the possible laboratory tests available on the market. The size, shape, and number of erythrocytes, and the number of hemoglobin molecules can have a major impact on a persons health. A cell that contains hemoglobin and can carry oxygen to the body. Feb 11, 2016 drugloaded erythrocytes as a slowrelease system. Can be used to explain about blood cancer, low blood count, and other topics in medicine related to blood.
Resealed erythrocytes as a carrier for drug targeting. Erythrocytes are produced in the bone marrow and sent into the circulation. Further shelf life of drugloaded erythrocytes was prolonged by lyophilization. Such drugloaded carrier erythrocytes are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers. Maternity powerpoint template is a free template with a pregnant mother and a light blue background. And because of this resealing process these carriers are. We use your linkedin profile and activity data to personalize ads and to show you more relevant ads.
Plural for a type of cell in the blood of vertebrates that contains haemoglobin and transports oxygen from the lungs to the tissues. The entrapment of drug does not require the chemical modification of the substance. This free blood cells powerpoint background contains blood cells images and is suitable for medicine presentations at classroom or hospitals. Resealed erythrocytes as carrier for drugs provides secure and more effective drug targeting for lon ger period of time and have advantage over several drugs carrier models regarding the. Download biology lab free editable powerpoint template now as you can use this biology lab free ppt template freely as sample. It is a part of the video lecture series for my bio 108 class at dyouville college. Introduction erythrocytes, the most abundant cells in the human. Hemoglobin is converted to a yellow pigment bilirubin, the iron is stored and protein is broken down to amino acids. Loaded erythrocytes 10% haematocrit, 5 ml are passed through a 23gauge hypodermic needle at a flow rate of 10 mlmin. Erythrocytes have been proposed as a carriers for a wide range of bioactive components including drugs enzymes, pesticides, dna molecules and others. Most of the resealed erythrocytes used as drug carriers are rapidly taken up from blood by macrophages of reticuloendothelial system res, which is present in. Blood contains different cells like erythrocytes rbc, leucocytes wbc and. Using this technique, drug present in the extracellular solution, it is possible to entrap up to 40 % of the drug inside the resealed erythrocyte and to use this system for targeted delivery via intravenous injection.
Blood contains various type of cells like erythrocytes rbc,wbc and platelets, among them the rbc are the most interesting carrier and posses great potential in drug delivery due to their ability to circulate throughout the body, zero order kinetics, reproducibility and ease of preparation. Drug loading in resealed erythrocytes osmotic lysis presswell method dialysis. Use the worksheet and quiz to identify study points to watch for. Bilirubin is transferred to the bile, released into the intestine and converted by bacteria to a yellow pigment. College of pharmacy, teerthanker mahaveer university, moradabad, uttar pradesh, india erythrocytes have been the most interesting carrier and have found to possess great potential in drug targeting.
Download table some properties of human erythrocytes processed for the. Institute of pharmaceutical sciences, udaipur rajasthan 301 erythrocytes, also known as red blood cells, have been extensively studied for their potential carrier capabilities for the delivery of drugs and drugloaded microspheres. Characterization of human erythrocytes as potential. In summary, counting pitted erythrocytes provides an excellent and quantitative method with which to evaluate splenic function. Applications of resealed erythrocytes resealed erythrocytes have several possible applications in various fields of human and veterinary medicine. Erythrocytes a blood cell, also called a hematocyte, is a cell produced by haematopoiesis and normally found in blood. A single drop of blood contains millions of erythrocytes and just thousands of leukocytes. This red powerpoint template with blood vessels and red blood cells will be a good illustration for presentation on erythrocytes, circulatory system, etc. Some properties of human erythrocytes processed for the. And because of this resealing process these carriers are called resealed erythrocytes. The erythrocyte, commonly known as a red blood cell or rbc, is by far the most common formed element.
If it is like this then you dont need to worry for this. Drug loading in resealed erythrocytes membrane perturbation electro encapsulation hypoosmotic lysis lipid. Presentation bypresentation by sunilboreddysunilboreddy m. Resealed erythrocytes as drug carriers pharmatutor. Erythrocytes are biconcave in shape, which increases the cells surface area and facilitates the diffusion of oxygen and carbon dioxide. From your question it is given in blood and urine test erythrocyte 0. Review your knowledge of what erythrocytes are and their role in the human body. May 26, 2015 by using various methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called resealed erythrocytes. Resealed erythrocyte free download as powerpoint presentation.
Characterization of human erythrocytes as potential carrier for pravastatin. Department of pharmaceutics, college of pharmacy, king saud university, p. Disseminated infection with mycobacterium avium complex mac remains the most. Resealed erythrocytes a specified tool in novel drug. Free download red blood cells powerpoint presentation slides. Describe the process of erythrocyte and hemoglobin breakdown. Nerves, md, fpsp erythropoiesis a process by which early erythroid precursor cells differentiate to become the mature rbcs. The drug is entrapped in the erythrocytes, and resealing the resultant cellular carriers. Download figure open in new tab download powerpoint. Hence, these carriers are called resealed erythrocytes. By using various methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called resealed erythrocytes. Contents introduction basic concept of rbc slideshow 2151823 by eli. Erythrocyte is biconcave discs, anucleate filled with hemoglobin hb, a protein that functions in.
In mammals, these fall into three general categories. Blood cells powerpoint template can be used to teach at classroom about blood cancer, also good for leukemia or acute lymphocytic leukemia or low platelet count, but also good for bleeding or haemorrhage powerpoint presentations or issue of blood in a powerpoint slide design. Free download the red blood cell powerpoint presentation. Thousands of new, highquality pictures added every day. Erythrocytes live up to 120 days in the circulation, after which the wornout cells are removed by a type of myeloid phagocytic cell called a macrophage, located primarily within the bone marrow, liver, and spleen. Resealed erythrocytes, 5flurouracil, encapsulation, hypotonicpreswelling, isotonicresealing.
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